The cytochrome P-450 content and catalytic activity in rat liver microsomes during hyperbaric oxygenation

The effect of different conditions of hyperbaric oxygenation (HBO) on content and catalytic activity of cytochrome P-450 in rat liver cytochrome has been studied. The intensity of lipid peroxidation in microsomal membranes has been determined by the content of dien conjugates and Schiff's bases...

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Bibliographic Details
Published in:	Nauchnye doklady vysshei shkoly. Biologicheskie nauki no. 12; p. 28
Main Authors:	Ananian, A A, Miliutina, N P, Shugaleĭ, V S, Sherstnev, K B, Kostkin, V B
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1991
Subjects:	Aminopyrine - pharmacokinetics Aniline Compounds - pharmacokinetics Animals Catalysis Cytochrome P-450 Enzyme System - metabolism Hyperbaric Oxygenation Lipid Peroxidation Male Microsomes, Liver - enzymology Rats Substrate Specificity
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Summary:	The effect of different conditions of hyperbaric oxygenation (HBO) on content and catalytic activity of cytochrome P-450 in rat liver cytochrome has been studied. The intensity of lipid peroxidation in microsomal membranes has been determined by the content of dien conjugates and Schiff's bases. The rate of amidopyrine demethylation has been shown not to change, but the rate of aniline hydroxylation decreases on 34, 57 and 64% under increase of oxygen pressure up to 0.3, 0.5 and 0.7 MPa correspondingly. The level of dien conjugates increase on 66-87% under all studied conditions of HBO. Cytochrome P-450 content decreases on 45% under the action of 0.7 MPa, but content of Schiff's bases increases on 210% as compared with control.
ISSN:	0470-4606