Effect of sodium thiosulfate on viable areas of the pancreas in experimental pancreatitis

Experimental pancreatitis in white rats is marked by stromal edema, dystrophic changes of acinar cells, with intracellular edema in an intact part of the pancreas. Subsequently the acinar cells undergo intracellular regeneration and hypertrophy, which is accompanied by intensive incorporation of 14C...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 96; no. 10; p. 68
Main Authors:	Kanaian, A S, Gabrielian, N A, Gevorkian, G A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-10-1983
Subjects:	Animals Antidotes Leucine - metabolism Pancreas - drug effects Pancreas - pathology Pancreatitis - drug therapy Pancreatitis - pathology Proteins - metabolism Rats Thiosulfates - therapeutic use
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Summary:	Experimental pancreatitis in white rats is marked by stromal edema, dystrophic changes of acinar cells, with intracellular edema in an intact part of the pancreas. Subsequently the acinar cells undergo intracellular regeneration and hypertrophy, which is accompanied by intensive incorporation of 14C-leucin into glandular proteins. Sodium thiosulfate prevents the development of stromal edema and intracellular edema of the acinar cells and retards the development of acinar cell hypertrophy. The drug produces an inhibitory action on 14C-leucin incorporation into pancreatic proteins.
ISSN:	0365-9615