Effect of gamma-aminobutyric acid on K+-induced and Ca++-dependent release of H3-noradrenaline from synaptosomes of the meso-diencephalic region of the rat brain

GABA exerted no effect on H3-NA release from synaptosomes in the presence of 20 mM K+ whereas it considerably reduced the release of H3--NA evoked by 40 mM K+ ions. The omission of Ca++ ions from the superfusion fluid reduced by H3-NA release; on the other hand, GABA in this condition enhanced consi...

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Bibliographic Details
Published in:	Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova Vol. 67; no. 7; p. 1001
Main Authors:	Chiflikian, M D, Armenian, A R, Buniatian, G Kh
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-1981
Subjects:	Animals Brain - metabolism Calcium - pharmacology Diencephalon - metabolism Drug Interactions gamma-Aminobutyric Acid - pharmacology In Vitro Techniques Male Mesencephalon - metabolism Norepinephrine - metabolism Potassium - pharmacology Rats Synaptosomes - metabolism
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Summary:	GABA exerted no effect on H3-NA release from synaptosomes in the presence of 20 mM K+ whereas it considerably reduced the release of H3--NA evoked by 40 mM K+ ions. The omission of Ca++ ions from the superfusion fluid reduced by H3-NA release; on the other hand, GABA in this condition enhanced considerably the release of H3-NA thus exhibiting Ca++-like effect. Thus in the absence of Ca++ or in the presence of its low (1 mM) concentrations the effects of GABA on the H3--NA release from the synaptosomes was reversed.
ISSN:	0015-329X