Contents of 6-keto-prostaglandin F1 alpha and thromboxane B2 in the blood of patients with bronchial asthma

There is a relationship between severity of bacterial bronchial asthma clinical symptoms and plasma 6-keto-PGF1 alpha, TxB2: in moderate disease against grave one as well as in clinical versus subclinical forms (remission) relevant indices are reduced. On the one hand elevated content of blood 6-ket...

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Bibliographic Details
Published in:	Klinicheskaia meditsina Vol. 68; no. 11; p. 26
Main Authors:	Grigorian, L G, Chervinskaia, T A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1990
Subjects:	6-Ketoprostaglandin F1 alpha - blood Adolescent Adult Asthma - blood Asthma - physiopathology Bronchi - physiopathology Constriction, Pathologic Female Humans Male Microcirculation Middle Aged Thromboxane B2 - blood
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Summary:	There is a relationship between severity of bacterial bronchial asthma clinical symptoms and plasma 6-keto-PGF1 alpha, TxB2: in moderate disease against grave one as well as in clinical versus subclinical forms (remission) relevant indices are reduced. On the one hand elevated content of blood 6-keto-PGF1 alpha seems compensatory rising in response to TxB2 bronchoconstriction. On the other hand, it impairs microcirculation and enhances mediators of inflammation, promotes exudation and edema of bronchoalveolar mucosa, thus contributing to obstruction.
ISSN:	0023-2149