Change in some properties of soluble cAMP-dependent protein kinase from rat myocardium during physical exercise

During 1.5- and 3-months physical exercise the activity of soluble 3':5'-AMP-dependent protein kinase of the rat increases 2.4- and 4.6-fold, respectively. The maximal activity of the enzymes from heart muscles of control and experimental animals is observed at the same concentration of 3&...

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Bibliographic Details
Published in:	Biokhimiia (Moscow, Russia) Vol. 48; no. 8; p. 1324
Main Authors:	Kalinskiĭ, M I, Kurskiĭ, M D
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-08-1983
Subjects:	Animals Cyclic AMP - pharmacology Heart - physiology Kinetics Male Myocardium - enzymology Physical Exertion Protein Kinases - metabolism Rats
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Summary:	During 1.5- and 3-months physical exercise the activity of soluble 3':5'-AMP-dependent protein kinase of the rat increases 2.4- and 4.6-fold, respectively. The maximal activity of the enzymes from heart muscles of control and experimental animals is observed at the same concentration of 3':5'-AMP (10(-6) M) and pH (6.8-7.0). The degree of changes in V and apparent Km for ATP and histone H2b depend on the duration of physical exercise. The changes in the properties of soluble 3':5'-AMP-dependent protein kinase suggest the participation of the enzyme in adaptation to systematic muscular activity.
ISSN:	0320-9725