Clinical, histopathologic, immunofluorescent and ultrastructural estimation of 2 cases of epidermolysis bullosa acquisita

Two cases of EBA were presented. Both patients with the symptoms of the disease were previously treated with nonsteroid antiinflammatory drugs. A considerable improvement of the patients condition has been noticed after the application of high doses of glucocorticosteroids. However, there were obser...

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Bibliographic Details
Published in:	Annales Universitatis Mariae Curie-Skłodowska. Sectio D, Medicina Vol. 45; p. 7
Main Authors:	Lecewicz-Toruń, B, Chibowska, M, Chibowski, D, Siezieniewska, Z
Format:	Journal Article
Language:	Polish
Published:	Poland 1990
Subjects:	Basement Membrane - chemistry Basement Membrane - ultrastructure Epidermolysis Bullosa Acquisita - pathology Female Fluorescent Antibody Technique Humans Male Middle Aged Skin - chemistry Skin - ultrastructure
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Summary:	Two cases of EBA were presented. Both patients with the symptoms of the disease were previously treated with nonsteroid antiinflammatory drugs. A considerable improvement of the patients condition has been noticed after the application of high doses of glucocorticosteroids. However, there were observed symptoms of a mild post-steroidal diabetes. In the histologically examined biopsies from lesions and from skin without any clinical changes were found subepidermal bulla containing serous fluid, erythrocytes and neutral granulocytes. At the patient no. 1 there were found linear deposits of IgG and fraction of C3 complement in the structure of a basal membrane. Ultrastructural research showed in both cases presence of subepidermal bulla located beneath lamina densa of a basal membrane. In the place of bulla there was observed a visible damage of anchoring fibres and collagen of a papillary layer of inner skin.
ISSN:	0066-2240