The use of the HPLC method for the quantitative determination of a peptide analog of piracetam with nootropic activity and its main metabolites

HPLC method has been developed for pharmacokinetic study of nootropic peptide analog of pyracetam GVS-111 and its main metabolites. In the model experiments on rats the enzymes of blood plasma were shown to metabolize GVS-111 during 1-h incubation with the formation of metabolite, phenylacetylprolin...

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Bibliographic Details

Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 59; no. 2; p. 38
Main Authors:	Boĭko, S S, Zherdev, V P, Gudasheva, T A, Vasilevich, N I, Ostrovskaia, R U, Voronina, T A, Rozantsev, G G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1996
Subjects:	Animals Chromatography, High Pressure Liquid - methods Liver - chemistry Male Nootropic Agents - analysis Nootropic Agents - pharmacokinetics Piracetam - analogs & derivatives Piracetam - analysis Piracetam - pharmacokinetics Rats Spectrophotometry, Ultraviolet
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