The use of the HPLC method for the quantitative determination of a peptide analog of piracetam with nootropic activity and its main metabolites

HPLC method has been developed for pharmacokinetic study of nootropic peptide analog of pyracetam GVS-111 and its main metabolites. In the model experiments on rats the enzymes of blood plasma were shown to metabolize GVS-111 during 1-h incubation with the formation of metabolite, phenylacetylprolin...

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Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 59; no. 2; p. 38
Main Authors:	Boĭko, S S, Zherdev, V P, Gudasheva, T A, Vasilevich, N I, Ostrovskaia, R U, Voronina, T A, Rozantsev, G G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1996
Subjects:	Animals Chromatography, High Pressure Liquid - methods Liver - chemistry Male Nootropic Agents - analysis Nootropic Agents - pharmacokinetics Piracetam - analogs & derivatives Piracetam - analysis Piracetam - pharmacokinetics Rats Spectrophotometry, Ultraviolet
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Summary:	HPLC method has been developed for pharmacokinetic study of nootropic peptide analog of pyracetam GVS-111 and its main metabolites. In the model experiments on rats the enzymes of blood plasma were shown to metabolize GVS-111 during 1-h incubation with the formation of metabolite, phenylacetylproline. This suggests that in vivo experiments these blood plasma enzymes will also be actively involved in the metabolism of the compound tested. The liver tissue enzymes metabolized GVS-111 much slower.
ISSN:	0869-2092