Experimental study of therapeutical properties and safety of king crab collagenase-containing ointment

The effects of ointment containing king crab (Paralithodes camtschatica) collagenase on intact skin, thermal, and pyonecrotic wounds were studied in rats by using hematological, biochemical, immunological, and morphological methods. The ointment for the skin and viscera was shown to be safe. It is h...

Full description

Saved in:

Bibliographic Details
Published in:	Vestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 4; p. 50
Main Authors:	Sandakhchiev, L S, Stavskiĭ, E A, Zinov'ev, V V, Nazarov, V P, Renau, I V, Satrikhina, T N, Katkova, L R, Krinitsin, L A, Kolesnikova, L V, Taranov, O S, Omigov, V V, Ovechkina, L G, Markovich, N A, Malygin, E G, Danilenko, E D, Voevoda, T V, Fedosova, L K, Sizova, L Iu, Masycheva, V I
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1998
Subjects:	Animals Anti-Infective Agents, Local - administration & dosage Anti-Infective Agents, Local - adverse effects Anti-Infective Agents, Local - isolation & purification Brachyura - enzymology Collagenases - administration & dosage Collagenases - adverse effects Collagenases - isolation & purification Disease Models, Animal Male Ointments Rats Rats, Inbred Lew Safety Treatment Outcome Wound Healing - drug effects Wound Infection - drug therapy Wound Infection - pathology
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The effects of ointment containing king crab (Paralithodes camtschatica) collagenase on intact skin, thermal, and pyonecrotic wounds were studied in rats by using hematological, biochemical, immunological, and morphological methods. The ointment for the skin and viscera was shown to be safe. It is highly effective in debriding the infected wounds. Different concentrations of collagenase were tested. The concentration of collagenase was recommended to be 0.2 mg/g ointment for use.
ISSN:	0869-6047