Effect of thyrotoxicosis on lipid fatty acid composition in various subcellular fractions of the rat brain

Effect of thyrotoxicosis on lipid fatty acid composition in various subcellular fractions of the rat brain

Thyrotoxicosis, which developed after subcutaneous administration of L-thyroxin at a dose of 400 micrograms/100 g of body mass, was accompanied by distinct alteration of fatty acid composition in lipids of adult rat brain myelin, synaptosomes, mitochondria and microsomes. The most significant altera...

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Bibliographic Details
Published in:Voprosy meditsinskoi khimii Vol. 37; no. 5; p. 63
Main Authors: Bliudzin, Iu A, Vilkova, V A, Zakharova, L I
Format: Journal Article
Language:Russian
Published: Russia (Federation) 01-09-1991
Subjects:
Animals
Brain - metabolism
Fatty Acids - metabolism
Male
Microsomes - metabolism
Mitochondria - metabolism
Myelin Sheath - metabolism
Rats
Synaptosomes - metabolism
Thyrotoxicosis - metabolism
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Summary:Thyrotoxicosis, which developed after subcutaneous administration of L-thyroxin at a dose of 400 micrograms/100 g of body mass, was accompanied by distinct alteration of fatty acid composition in lipids of adult rat brain myelin, synaptosomes, mitochondria and microsomes. The most significant alterations were detected in synaptosomes and mitochondria. Under conditions of thyrotoxicosis the ratio of polyunsaturated docosahexaenic and docosatetraenic acids was decreased in synaptosome lipids, whereas the content of palmitic, oleic and neuronic acids was increased. The ratio of unsaturated arachidonic and docosahexaenic fatty acids was increased but content of palmitic and linoleic acids was decreased in mitochondrial lipids.
ISSN:0042-8809