Action of adaptogens: cucurbitacin R diglucoside as a stimulator of arachidonic acid metabolism in the rat adrenal gland

It has been demonstrated that cucurbitacin R diglucoside (CRD), an adaptogen increasing the rat working capacity and stimulating corticosteroid secretion, stimulates the release of arachidonic acid (AA) in the rat adrenal cortex in vivo (the administration of CRD during 14 days) as well as in vitro...

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Bibliographic Details
Published in:	Problemy ėndokrinologii Vol. 35; no. 2; p. 70
Main Authors:	Panosian, A G, Dadaian, M A, Gevorkian, G A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1989
Subjects:	Adrenal Cortex - drug effects Adrenal Cortex - metabolism Adrenal Cortex Hormones - biosynthesis Adrenocorticotropic Hormone - physiology Animals Arachidonic Acids - metabolism Dinoprostone - metabolism Fatty Acids - metabolism Fatty Acids, Nonesterified - metabolism Fatty Acids, Unsaturated - biosynthesis Hydroxyeicosatetraenoic Acids - biosynthesis Male Rats Restraint, Physical Stress, Physiological - metabolism Triterpenes - pharmacology
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Summary:	It has been demonstrated that cucurbitacin R diglucoside (CRD), an adaptogen increasing the rat working capacity and stimulating corticosteroid secretion, stimulates the release of arachidonic acid (AA) in the rat adrenal cortex in vivo (the administration of CRD during 14 days) as well as in vitro (the incubation of isolated rat adrenocortical cells with CRD in the presence of eicosatetraenoic acid, the AA metabolism inhibitor) experiments. The incubation of isolated rat adrenocortical cell with CRD in the presence of AA increases the biosynthesis of 5-HETE, the precursor of which 5-HPETE is known to be a modulator of ACTH-induced corticosteroid secretion.
ISSN:	0375-9660