Evaluation of the quality of radiopharmaceutics

Evaluation of the quality of radiopharmaceutics

The authors considered the interrelationship of clinical requirements and analytical indicators of quality for a group of pharmaceuticals: radionuclide purity (by the criteria of dose load and the quality of visualization); radiochemical purity (interrelationship with a necessary level of accumulati...

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Bibliographic Details
Published in:Meditsinskaia radiologiia Vol. 36; no. 4; p. 27
Main Authors: Korsunskiĭ, V N, Tarasov, N F, Kodina, G E, Malinin, A B
Format: Journal Article
Language:Russian
Published: Russia (Federation) 1991
Subjects:
Chromatography, High Pressure Liquid
Electrophoresis
Evaluation Studies as Topic
Radioisotopes - analysis
Radioisotopes - pharmacokinetics
Radioisotopes - standards
Safety
Tissue Distribution
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Summary:The authors considered the interrelationship of clinical requirements and analytical indicators of quality for a group of pharmaceuticals: radionuclide purity (by the criteria of dose load and the quality of visualization); radiochemical purity (interrelationship with a necessary level of accumulation in investigated organs); chemical admixtures (by the criteria of safety and influence on the diagnostic quality; clinical criteria of quality were under discussion); a coefficient of differential accumulation in the system: organ under study-adjacent tissues; specificity; indices of pharmacokinetics, etc. Correct and all-round evaluation of RP quality on the basis of the above criteria determines, to a great extent, a choice of a labeled compound to be used in a specific radionuclide diagnostic method.
ISSN:0025-8334