Inhibiting effect of ADP-ribosylation by pertussis toxin on passive transport of Ca2+ into the cell membrane of porcine myometrium

ADP-ribosylation by whooping cough toxin of protein components of inside-out oriented vesicles of pig myometrium plasma membranes under conditions of their depolarization results in significant inhibition of passive transport of Ca2+ ions. The inhibiting effect is dose- and time-dependent. rho-Chlor...

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Bibliographic Details
Published in:	Biokhimiia (Moscow, Russia) Vol. 57; no. 11; p. 1751
Main Authors:	Kurskiĭ, M D, Kropotova, S A, Prishchepa, L A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1992
Subjects:	Adenosine Diphosphate Ribose - metabolism Animals Biological Transport - drug effects Calcium - metabolism Cations, Divalent Cell Membrane - metabolism Female In Vitro Techniques Myometrium - metabolism Pertussis Toxin Swine Virulence Factors, Bordetella - pharmacology
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Summary:	ADP-ribosylation by whooping cough toxin of protein components of inside-out oriented vesicles of pig myometrium plasma membranes under conditions of their depolarization results in significant inhibition of passive transport of Ca2+ ions. The inhibiting effect is dose- and time-dependent. rho-Chloromercuribenzoate (0.5 mM) blocks the effect of whooping cough toxin, no such effect on Ca2+ transport being observed in control preparations.
ISSN:	0320-9725