DNA typing of HLA class II genes among the aboriginal inhabitants of Chukotka

Polymorphism of class II HLA genes was studied in native Chukotka inhabitants with the use of DNA oligotyping. The characteristics of the distribution of allelic variants of the loci HLA-DRB1, -DQA1, -DQB1, and -DPB1 were revealed; they were similar to those of other Subarctic Mongoloid populations...

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Bibliographic Details
Published in:	Genetika Vol. 31; no. 6; p. 852
Main Authors:	Krylov, M Iu, Erdes, Sh, Alekseeva, L I, Benevolenskaia, L I
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-06-1995
Subjects:	Alleles Asian Continental Ancestry Group - genetics Base Sequence Continental Population Groups DNA Primers Genes, MHC Class II Humans Molecular Sequence Data Oceanic Ancestry Group - genetics Polymorphism, Genetic Russia Russia
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Summary:	Polymorphism of class II HLA genes was studied in native Chukotka inhabitants with the use of DNA oligotyping. The characteristics of the distribution of allelic variants of the loci HLA-DRB1, -DQA1, -DQB1, and -DPB1 were revealed; they were similar to those of other Subarctic Mongoloid populations and different from those for comparable populations of other climatic and geographic zones. Our data suggest that the specific features found for the distributions of some alleles of the loci examined are related to the geographic variation in the HLA gene system studied.
ISSN:	0016-6758