Changes in the phospholipid-phospholipid ratio and lipid peroxidation in the heart muscle in experimental myocardial infarction before and after combined antioxidant therapy

Dynamics of quantitative relations between neutral and acid phospholipids in rabbit myocardium was studied with simultaneous registration of lipid free radical oxidation (estimated by malonic dialdehyde content) in NADP-dependent system of oxidation within various periods after simulation of myocard...

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Bibliographic Details
Published in:	Voprosy meditsinskoi khimii Vol. 31; no. 1; p. 43
Main Authors:	Engibarian, A A, Karagezian, K G, Ovakimian, S S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1985
Subjects:	Animals Antioxidants - pharmacology Antioxidants - therapeutic use Drug Therapy, Combination Lipid Peroxides - metabolism Male Malondialdehyde - metabolism Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Myocardium - metabolism Nucleic Acids - administration & dosage Nucleic Acids - pharmacology Phospholipids - metabolism Rabbits Time Factors Vitamin E - administration & dosage Vitamin E - pharmacology
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Summary:	Dynamics of quantitative relations between neutral and acid phospholipids in rabbit myocardium was studied with simultaneous registration of lipid free radical oxidation (estimated by malonic dialdehyde content) in NADP-dependent system of oxidation within various periods after simulation of myocardial infarction in the animals treated with alpha-tocopherol and sodium nucleinate 2 and 25 mg/kg of body mass, respectively) and did not receiving the drugs. The complex treatment led to normalization of qualitative and quantitative relations between phospholipids in the impaired myocardium and to decrease the lipid peroxidation in myocardium infarction.
ISSN:	0042-8809