Genome instability and neoplasia

Necessity of oncogene for the neoplastic cell transformation is substantiated. The oncogene may be introduced into the cell by a virus; be present in the cell from its formation but be repressed by products of regulatory genes; be arisen from separated DNA segments. The latter possibility is discuss...

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Bibliographic Details
Published in:	TSitologiia i genetika Vol. 15; no. 6; p. 73
Main Authors:	Shapot, V S, Mironov, N M
Format:	Journal Article
Language:	Russian
Published:	Ukraine 01-11-1981
Subjects:	Animals Carcinogens Cell Transformation, Neoplastic - ultrastructure DNA Transposable Elements DNA, Neoplasm - genetics DNA, Viral - genetics Genes Genes, Regulator Molecular Weight Mutation Neoplasms, Experimental - etiology Neoplasms, Experimental - genetics Oncogenic Viruses - genetics Oncogenic Viruses - pathogenicity RNA, Viral - genetics Transfection Transformation, Genetic Virus Activation
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Summary:	Necessity of oncogene for the neoplastic cell transformation is substantiated. The oncogene may be introduced into the cell by a virus; be present in the cell from its formation but be repressed by products of regulatory genes; be arisen from separated DNA segments. The latter possibility is discussed in view of data on the presence of mobile elements and Sarc sequences in the cell genome.
ISSN:	0564-3783