Changes in the serum activity of lysosome enzymes in rats after application of the insecticide propoxur (Baygon)

The effect of repeated peroral introduction (4 times) of 1/4 and 1/20 LD50 of monomethylcarbamate insecticide Propoxur (Baygon) on the activity of two lysosomal enzymes (beta-N-acetylglucosaminidase and alpha-mannosidase) is studied in the serum of white male rats with starting weight 300 g. Upon us...

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Bibliographic Details
Published in:	Problemi na khigienata Vol. 1; p. 207
Main Authors:	Apostolov, I, Ribarova, F, Pramatarova, V
Format:	Journal Article
Language:	Bulgarian
Published:	Bulgaria 1975
Subjects:	Acetylglucosaminidase - blood Administration, Oral Animals Disaccharidases - blood Dose-Response Relationship, Drug Enzyme Activation - drug effects Hexosaminidases - blood Lethal Dose 50 Lysosomes - enzymology Male Mannosidases - blood Propoxur - toxicity Rats Time Factors
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Summary:	The effect of repeated peroral introduction (4 times) of 1/4 and 1/20 LD50 of monomethylcarbamate insecticide Propoxur (Baygon) on the activity of two lysosomal enzymes (beta-N-acetylglucosaminidase and alpha-mannosidase) is studied in the serum of white male rats with starting weight 300 g. Upon using the higher dose, a statistically significant rise (p less than 0.02) of the activity of either of the enzymes is established. The results obtained are interpreted as a sign of impaired permeability of the lysosomal and cell membrane.
ISSN:	0323-9179