The study of the interaction of antineoplastic drugs mitoxantrone and ametantrone with DNA using the analysis of changes in circular dichroism spectra

The influence of the ionic strength and temperature of medium on the changes in the geometry of the double stranded DNA of different nucleotide content upon the formation of complexes with antitumor drugs mitoxantrone and ametantrone was investigated. It is shown that from circular dichroism spectra...

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Bibliographic Details
Published in:	Biofizika Vol. 43; no. 3; p. 422
Main Authors:	Babaian, Iu S, Sngrian, A E, Kazarian, R S, Avetisian, M G, Sogomonian, L R, Garibian, D V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-1998
Subjects:	Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Circular Dichroism DNA, Bacterial - chemistry DNA, Bacterial - drug effects DNA, Bacterial - metabolism Micrococcus Mitoxantrone - analogs & derivatives Mitoxantrone - metabolism Mitoxantrone - pharmacology
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Summary:	The influence of the ionic strength and temperature of medium on the changes in the geometry of the double stranded DNA of different nucleotide content upon the formation of complexes with antitumor drugs mitoxantrone and ametantrone was investigated. It is shown that from circular dichroism spectra it is possible to determine the relative intensity of changes in the geometry of DNA double helix upon binding with the drugs investigated. The binding of one ametantrone molecule causes greater changes in the geometry of DNA double helix than the binding of mitoxantrone.
ISSN:	0006-3029