Kinetics of hepatotropic radiopharmaceuticals

• Published in: Meditsinskaia radiologiia Vol. 30; no. 9; p. 41
• Main Authors: Bogdanovich, A I, Tarasov, N F, Korsunskiĭ, V N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-09-1985
• Subjects: Absorption; Biliary Tract - diagnostic imaging; Biliary Tract - metabolism; Bilirubin - blood; Cholestasis - diagnostic imaging; Cholestasis - metabolism; Humans; Imino Acids - metabolism; Iodine Radioisotopes - metabolism; Kinetics; Liver - diagnostic imaging; Liver - metabolism; Radioisotopes - metabolism; Radionuclide Imaging; Technetium - metabolism; Time Factors; Whole-Body Counting
• ISSN: 0025-8334

A study was made of the biological distribution of 131I labeled stains and 99mTc labeled iminodiacetic acid derivatives in 153 patients of whom 98 suffered from jaundice of different genesis. Significant differences of their behavior in the human body depending on the chemical structure of the compound were revealed. Blood clearance for the iminodiacetic acid derivatives was 1.5-2 times as high as compared to that for the labeled stains. The rate of transit via the hepatocyte was the highest in 99mTc-MESIDA (USSR) 99mTc-DIDA and 99mTc-TIDA. The rate and volume of the renal excretion of the radiopharmaceutical depended on the main substance molecular structure. Retarded blood clearance lowered excretion of the radiopharmaceuticals by the liver and their considerable excretion with urine were observed. The Soviet radiopharmaceuticals 99mTc-MESIDA and 99mTc-BUTILIDA by their pharmacokinetic characteristics and quality were in no way inferior to the best foreign analogs.