Cardiotoxicity of 5-fluorouracil. Spasm or direct myocardial toxicity?

The authors report on a case of cardiotoxicity observed during a protocol including a 5-day continuous infusion of 5-fluorouracil; anginal manifestations recurred during a second treatment course. Coronary angiography, thallium scintigraphy and methergine test were all normal. An attempt to prevent...

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Bibliographic Details
Published in:	Bulletin du cancer Vol. 74; no. 4; p. 381
Main Authors:	Thyss, A, Falewee, M N, Leborgne, L, Viens, P, Schneider, M, Demard, F
Format:	Journal Article
Language:	French
Published:	France 1987
Subjects:	Aged Coronary Vasospasm - chemically induced Coronary Vasospasm - physiopathology Electrocardiography Female Fluorouracil - adverse effects Heart - drug effects Humans Male Middle Aged
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Summary:	The authors report on a case of cardiotoxicity observed during a protocol including a 5-day continuous infusion of 5-fluorouracil; anginal manifestations recurred during a second treatment course. Coronary angiography, thallium scintigraphy and methergine test were all normal. An attempt to prevent the recurrence of such manifestations using a calcium inhibitor and nitroderivatives was unsuccessful. In connection with this case, six other with anginal manifestation and four sudden deaths under the same protocol, a review of the relevant literature is included in the discussion on the factors that may favor cardiotoxicity and the different etiopathogenic hypothesis. The generally accepted hypothesis is a coronary spasm but a direct cardiotoxicity of 5-FU cannot be. The only therapeutic possibility appears to be the definitive halt of 5-FU after the onset of such manifestations.
ISSN:	0007-4551