Phospholipid biosynthesis in the lungs in a chronic inflammatory bronchopulmonary process

Glycerokinase, glycerophosphate dehydrogenase, glycerophosphate acyltransferase activity, glycerophosphate, dioxiacetonphosphate level and in vivo incorporation of (U-14C)-glucose into the lung phospholipid structure were studied in normal rats and in conditions of chronic bronchopulmonary inflammat...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 101; no. 3; p. 296
Main Authors:	Kazarian, P A, Karagezian, K G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1986
Subjects:	Animals Bronchopneumonia - enzymology Chronic Disease Glucose - metabolism Lung - enzymology Male Phospholipids - biosynthesis Pulmonary Surfactants - biosynthesis Rabbits
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Summary:	Glycerokinase, glycerophosphate dehydrogenase, glycerophosphate acyltransferase activity, glycerophosphate, dioxiacetonphosphate level and in vivo incorporation of (U-14C)-glucose into the lung phospholipid structure were studied in normal rats and in conditions of chronic bronchopulmonary inflammation. The inhibition of glycerokinase and glycolytic ways of glycerophosphate formation was demonstrated. The data obtained have shown that glucose incorporation into phosphatidyl cholines, phosphatidyl glycerols and phosphatidyl ethanolamines was decreased, while the incorporation of radioactivity into the sphingomyelins and lysophosphatidyl cholines was significantly activated.
ISSN:	0365-9615