Analysis of the role of calcium in analgesic action of non-narcotic analgesics and calcium channel blockers

In the mice hot-plate test we have compared analgesic effect of calcium channel blockers and new non-narcotic analgesic antiinflammatory agent PV-107: verapamil > fenigidin > PV-107. Simultaneously we have shown strong correlation (r - 0.82) between analgesic effect and 45Ca2+ efflux of cardia...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 113; no. 5; p. 508
Main Authors:	Trinus, F P, Kurskiĭ, M D, Gubskiĭ, Iu I, Bukhtiarova, T A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-1992
Subjects:	Analgesics Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Calcium - metabolism Calcium - physiology Calcium Channel Blockers - pharmacology Male Mice Nifedipine - pharmacology Pain Measurement Time Factors Verapamil - pharmacology
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Summary:	In the mice hot-plate test we have compared analgesic effect of calcium channel blockers and new non-narcotic analgesic antiinflammatory agent PV-107: verapamil > fenigidin > PV-107. Simultaneously we have shown strong correlation (r - 0.82) between analgesic effect and 45Ca2+ efflux of cardiac membrane in depolarizing media in vitro.
ISSN:	0365-9615