Anaphylactic reactions to modified fluid gelatins. (A case of allergy to Plasmagel)

A case of anaphylactic reaction to an infusion of modified fluid gelatin (Plasmagel) which occurred just before the induction of anaesthesia is reported. The allergic origin of this side effect was sought by a human basophil degranulation test (Benveniste test) which proved to be positive. Intoleran...

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Bibliographic Details
Published in:	Annales de l'anesthesiologie francaise Vol. 21; no. 2; p. 148
Main Authors:	Saissy, J M, Legoury, O, Bonvalot, C, Vilette, B
Format:	Journal Article
Language:	French
Published:	France 1980
Subjects:	Aged Anaphylaxis - chemically induced Drug Hypersensitivity - etiology Gelatin - adverse effects Humans Male
Online Access:	Get more information
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Summary:	A case of anaphylactic reaction to an infusion of modified fluid gelatin (Plasmagel) which occurred just before the induction of anaesthesia is reported. The allergic origin of this side effect was sought by a human basophil degranulation test (Benveniste test) which proved to be positive. Intolerance reactions to gelatins have up to now been little described in the French literature (in contrast to the German literature). Their mechanism remains poorly understood, even though there are many arguments in favour of a sensitivation phenomenon which would confirm the antigenic role, denied by some, of modified fluid gelatins employed in human clinical use (with the possibility of crossover allergy). The diagnosis and treatment of such complications are reviewed in the light of their mechanism.
ISSN:	0003-4061