Relationship between surface HLA-DR expression and NBT reduction in monocytes in patients with colorectal cancer

The expression of HLA-DR antigens and their capacity to reduce nitroblue tetrazolium (NBT) have been evaluated in monocytes (Mo) from 28 patients with colorectal carcinoma (CCa) before antineoplastic treatment as well as in 29 normal control (NC). Simultaneously, circulating immune complexes (CIC) l...

Full description

Saved in:

Bibliographic Details
Published in:	Sangre (Zaragoza) Vol. 36; no. 2; p. 99
Main Authors:	Novellino, P S, Trejo, Y G, Fernández, O, Bordenave, H, Rumi, L S
Format:	Journal Article
Language:	Spanish
Published:	Spain 01-04-1991
Subjects:	Antigen-Antibody Complex - analysis Colorectal Neoplasms - blood Colorectal Neoplasms - immunology HLA-DR Antigens - analysis Humans Monocytes - metabolism Nitroblue Tetrazolium - metabolism Oxidation-Reduction
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The expression of HLA-DR antigens and their capacity to reduce nitroblue tetrazolium (NBT) have been evaluated in monocytes (Mo) from 28 patients with colorectal carcinoma (CCa) before antineoplastic treatment as well as in 29 normal control (NC). Simultaneously, circulating immune complexes (CIC) levels were studied in both groups. The results were expressed as the media of percentages. They show a decrease of Mo bearing HLA-DR (p less than 0.001 vs NC) and increase of MO with capacity to reduce NBT (p less than 0.001 vs NC). An increase of CIC levels in CCa compared to the NC (p less than 0.001) was also observed. We can postulate that the decrease in HLA-DR expression could be caused by the increase of toxic oxygen intermediates whose production was induced by CIC or tumoral antigens adherence.
ISSN:	0036-4355