Metabolic and morphological disorders of the brain under hypokinesia and their pharmacological correction

Experiments on rats have established that hypokinetic life leads to morphological and metabolic changes in tissue. Simultaneously, there is a negative dynamics in rheological and vascular changes. GABAergic substances have been found to have a tendency to level off morphological changes from 15 to 4...

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Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 56; no. 5; p. 8
Main Authors:	Akopian, V P, Kanaian, A S, Gevorkian, G A, Melkonian, K V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-1993
Subjects:	Animals Bicuculline - pharmacology Brain - drug effects Brain - metabolism Brain - pathology Carbon Dioxide - metabolism Carbon Radioisotopes gamma-Aminobutyric Acid - pharmacology Immobilization - physiology Male Periodic Acid-Schiff Reaction Rats Time Factors
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Summary:	Experiments on rats have established that hypokinetic life leads to morphological and metabolic changes in tissue. Simultaneously, there is a negative dynamics in rheological and vascular changes. GABAergic substances have been found to have a tendency to level off morphological changes from 15 to 45 days of experimental investigations, but no later and they are of great energy value for brain tissue by stimulation of glucose utilization rates.
ISSN:	0869-2092