Effect of piracetam on the habituation of the neuronal cholinoreceptor membrane of the edible snail

Piracetam is shown to modulate the habituation pattern of cholinoreceptor neuronal membrane in Helix lucorum. Piracetam (10(-2) M) intensified the reversible decrease of depolarization and spike discharge induced by the local microionophoretic rhythmical application of acetylcholine to the neuron so...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 104; no. 7; p. 51
Main Authors:	Pivovarov, A S, Ostrovskaia, R U, Drozdova, E I, Saakian, S A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-1987
Subjects:	Acetylcholine - pharmacology Animals Habituation, Psychophysiologic - drug effects Helix (Snails) - drug effects Iontophoresis Membrane Potentials - drug effects Neurons - drug effects Piracetam - pharmacology Pyrrolidinones - pharmacology Receptors, Cholinergic - drug effects
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Summary:	Piracetam is shown to modulate the habituation pattern of cholinoreceptor neuronal membrane in Helix lucorum. Piracetam (10(-2) M) intensified the reversible decrease of depolarization and spike discharge induced by the local microionophoretic rhythmical application of acetylcholine to the neuron soma. The ability of piracetam to intensify the habituation of neuronal cholinoreceptor membrane may serve as a model of its facilitating effect on the development of habituation of behavioural reactions. Piracetam (5.10(-2) M) was shown to induce a shift in the membrane potential towards depolarization in the majority of identified neurons studied.
ISSN:	0365-9615