Effect of anti-angina therapy on phospholipid levels of the myocardium in ischemic lesions

Antianginal treatment of animals with experimentally induced myocardial ischemia produced significant effects on the quantitative and qualitative composition of phospholipids: total phospholipids returned to normal levels, cardiolipins and phosphatidilinosytes were drastically increased. In ischemia...

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Bibliographic Details
Published in:	Kardiologiia Vol. 28; no. 10; p. 88
Main Authors:	Dzhanpoladian, E G, Karagezian, K G, Sambelian, V M, Aloian, G A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-10-1988
Subjects:	Animals Coronary Disease - drug therapy Coronary Disease - metabolism Dioxanes - therapeutic use Male Myocardium - metabolism Nitroglycerin - therapeutic use Phospholipids - metabolism Propranolol - therapeutic use Pyrrolidines - therapeutic use Rats
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Summary:	Antianginal treatment of animals with experimentally induced myocardial ischemia produced significant effects on the quantitative and qualitative composition of phospholipids: total phospholipids returned to normal levels, cardiolipins and phosphatidilinosytes were drastically increased. In ischemia, this lipid metabolism derangement appears to be of great significance as it enables the physiochemical status of biological membranes to be relatively stabilized, which is an essential condition for the enzymic system of cardiomyocytes to act.
ISSN:	0022-9040