Structural characteristics of DNA from sarcoma 45

It is shown that thermodynamical parameters of thermal melting and the content of 5-methylcytosine for tumor DNA of sarcoma 45 differ from DNA in the norm. The reason of such difference is the presence of regions with changed DNA structure in sarcoma 45, which occurs apparently owing to hypermethyla...

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Bibliographic Details
Published in:	Biofizika Vol. 35; no. 4; p. 592
Main Authors:	Babaian, Iu S, Garibian, D V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-1990
Subjects:	5-Methylcytosine Animals Base Composition Calorimetry, Differential Scanning Circular Dichroism Cytosine - analogs & derivatives Cytosine - chemistry DNA - chemistry DNA, Neoplasm - chemistry Liver - chemistry Male Nucleic Acid Conformation Rats Sarcoma, Experimental - chemistry Thermodynamics
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Summary:	It is shown that thermodynamical parameters of thermal melting and the content of 5-methylcytosine for tumor DNA of sarcoma 45 differ from DNA in the norm. The reason of such difference is the presence of regions with changed DNA structure in sarcoma 45, which occurs apparently owing to hypermethylation of cytosine in tumor DNA.
ISSN:	0006-3029