The hypolipidemic action of water-soluble enterosorbents of cholesterol and bile acids in an experiment

Experiments on rats, guinea pigs and rabbits with experimental dyslipoproteinemia have revealed that the new water-soluble high-molecular weight polymers containing digitonin (ED) or a quaternary nitrogen atom (EA) have a more marked hypolipidemic action than cholestyramine and normalize lipoprotein...

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Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 55; no. 5; p. 41
Main Authors:	Chistiakova, A M, Frolova, Iu V, Triufanov, V F, Vasil'eva, L E, Lozovskiĭ, V T, Ryzhenkov, V E
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-1992
Subjects:	Animals Bile Acids and Salts - metabolism Cholesterol - metabolism Cholesterol, Dietary - administration & dosage Digitonin - therapeutic use Enterosorption - methods Evaluation Studies as Topic Guinea Pigs Hypercholesterolemia - etiology Hypercholesterolemia - metabolism Hypercholesterolemia - therapy Hypolipidemic Agents - therapeutic use Male Mice Molecular Weight Nitrogen - therapeutic use Polymers - therapeutic use Rabbits Rats Solubility
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Summary:	Experiments on rats, guinea pigs and rabbits with experimental dyslipoproteinemia have revealed that the new water-soluble high-molecular weight polymers containing digitonin (ED) or a quaternary nitrogen atom (EA) have a more marked hypolipidemic action than cholestyramine and normalize lipoprotein metabolism. The digitonin-containing enterosorbent has been shown to decrease the absorption of 4-14C-cholesterol, while the nitrogen-containing enterosorbent diminishes the absorption of 3H-cholic acid.
ISSN:	0869-2092