Neurospecific protein-hormonal complexes

New cardioactive protein-hormone complexes (PHC) were identified, and then separated and purified in magnocellular foci of hypothalamus of oxen and some other animals. It was proved that the PHC are specific for nervous tissue, their subsell localisation was studied, concentration and distribution i...

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Bibliographic Details
Published in:	Uspekhi fiziologicheskikh nauk Vol. 27; no. 1; p. 21
Main Author:	Srapionian, R M
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1996
Subjects:	Animals Carrier Proteins - physiology Chemical Phenomena Chemistry, Physical Glycoproteins - physiology Heart - drug effects Hypothalamic Hormones - physiology Hypothalamus - physiology Molecular Weight Nerve Tissue Proteins - physiology Organ Specificity
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Summary:	New cardioactive protein-hormone complexes (PHC) were identified, and then separated and purified in magnocellular foci of hypothalamus of oxen and some other animals. It was proved that the PHC are specific for nervous tissue, their subsell localisation was studied, concentration and distribution in an organism were identified. It was discovered, that under dissociation of PHC, its high-molecular "apoforms" represent new specific glicoproteins, and the low-molecular combinations related to them in a non-covalent way are glicopeptides with clear cardioactive properties inherent in the respective native PHC. The above glicoproteins are transport molecules for the cardioactive neurohormones of hypothalamus, and are the basis for mediation of the inter-neurone interaction and the finction of intracellular connection. In addition, it was proved that these glicoproteins can exist in the form of preprohormone forms of cardiotropic neurohormones of hypothalamus: "K", "S", and "G".
ISSN:	0301-1798