Comparative study of permeability of derivatives of gamma-aminobutyric and gamma-hydroxybutyric acids through hemato-encephalic barrier

The authors studied the permeability of the blood-brain barrier (CEB) to two nootropics: calcium ketogomopantothenate (KRA-Ca), a GABA derivative, and and calcium salt of oxybutyrate (OB-Ca), a derivative of GOBA. It was established that both preparations penetrate the CEB easily and are found in th...

Full description

Saved in:

Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 60; no. 6; p. 52
Main Authors:	Nasybullina, N M, Zherdev, V P, Gunar, V I, Kopelevich, V M, Kozlova, G S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1997
Subjects:	Animals Blood-Brain Barrier - physiology Brain - metabolism gamma-Aminobutyric Acid - analogs & derivatives gamma-Aminobutyric Acid - pharmacokinetics Nootropic Agents - pharmacokinetics Permeability Rats Rats, Wistar Sodium Oxybate - pharmacokinetics
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The authors studied the permeability of the blood-brain barrier (CEB) to two nootropics: calcium ketogomopantothenate (KRA-Ca), a GABA derivative, and and calcium salt of oxybutyrate (OB-Ca), a derivative of GOBA. It was established that both preparations penetrate the CEB easily and are found in the brain at different intervals after their administration. However, essential differences in the distribution constant of these drugs were disclosed: KPA-Ca permeated the CEB more intensively and was accumulated in larger amounts in the late-term intervals.
ISSN:	0869-2092