Blood levels of reduced and oxidized glutathione in malignant and non-malignant human colorectal lesions

Glutathione blood levels were determined in colorectal cancer patients (n = 10), patients with adenomatous colorectal polyps (n = 8), and healthy subjects (control group; n = 10). Mean GSH level (micrograms/ml) was significantly higher in cancer patients [515.4 +/- 76.1 (S.D.)] than in those with po...

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Bibliographic Details
Published in:	European journal of cancer (1990) Vol. 26; no. 2; p. 89
Main Authors:	Boisio, M L, Merlo, F, Martines, H, Esposito, M
Format:	Journal Article
Language:	English
Published:	England 01-02-1990
Subjects:	Adult Aged Colorectal Neoplasms - blood Female Glutathione - analogs & derivatives Glutathione - blood Glutathione Disulfide Humans Intestinal Polyps - blood Male Middle Aged Oxidation-Reduction Precancerous Conditions - blood
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Summary:	Glutathione blood levels were determined in colorectal cancer patients (n = 10), patients with adenomatous colorectal polyps (n = 8), and healthy subjects (control group; n = 10). Mean GSH level (micrograms/ml) was significantly higher in cancer patients [515.4 +/- 76.1 (S.D.)] than in those with polyps [407.7 +/- 90.5 (S.D.), P less than 0.05] and the control group [360.9 +/- 67.9 (S.D.), P less than 0.001]. Statistically significant lower GSSG blood level were observed in cancer patients when compared to the other groups. The highest mean blood GSH/GSSG ratio (log transformed) was observed in cancer patients [2.17 +/- 0.108 (S.D.)] and the lowest in healthy subjects [1.88 +/- 0.032 (S.D.)]. All between-group differences in the GSH/GSSG ratio were statistically significant. These findings suggest that glutathione blood levels as well as GSH/GSSG ratio may have applicability as a guide for following the activity of colorectal diseases.
ISSN:	0959-8049