The effect of steroid hormones and tamoxifen on the rate of phospholipid turnover in the cells of uterine and breast tumors

• Published in: Vestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 3; p. 43
• Main Authors: Krasil'nikov, M A, Shatskaia, V A, Kuz'mina, Z V, Barinov, V V, Letiagin, V P, Bassalyk, L S
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1993
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - metabolism; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Drug Screening Assays, Antitumor; Epidermal Growth Factor - pharmacology; Estradiol - pharmacology; Estradiol - therapeutic use; Female; Humans; Phospholipids - metabolism; Phosphorus Radioisotopes; Progesterone - pharmacology; Progesterone - therapeutic use; Protein Kinase C - drug effects; Protein Kinase C - metabolism; Tamoxifen - pharmacology; Tamoxifen - therapeutic use; Tumor Cells, Cultured - drug effects; Tumor Cells, Cultured - metabolism; Uterine Neoplasms - drug therapy; Uterine Neoplasms - metabolism
• ISSN: 0869-6047

The cycle of phospholipid turnover has been found to be under the negative control of hormonal cytostatics (progesterone) and under the positive control of proliferation stimulants (17 beta-estradiol, epidermal growth factor). Specific changes in the synthesis of phospholipids are shown when tamoxiphen, an antiestrogen and an inhibitor of protein kinase C, was used. The findings suggest that changes in the turnover rate of phospholipids are one of the key stages of steroid action on target cells and may be regarded as an additional criterion of tumor genetic sensibility.