Morphochemical changes in the brain in experimental hypothyroidism

Under conditions of experimentally induced thyroid insufficiency a number of structural changes were revealed in the brain tissues and the pia mater. Of a particular importance among them were changes in the vessels of the microcirculation system that manifested themselves in the form of disturbed m...

Full description

Saved in:

Bibliographic Details
Published in:	Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) Vol. 81; no. 7; p. 981
Main Author:	Gasparian, E I
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1981
Subjects:	Animals Arachnoid - pathology Arteries - metabolism Arterioles - metabolism Biogenic Amines - metabolism Brain - blood supply Brain - pathology Glycosaminoglycans - metabolism Histocytochemistry Hypothyroidism - metabolism Hypothyroidism - pathology Lipid Metabolism Male Rats
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Under conditions of experimentally induced thyroid insufficiency a number of structural changes were revealed in the brain tissues and the pia mater. Of a particular importance among them were changes in the vessels of the microcirculation system that manifested themselves in the form of disturbed metabolism of acidic mucopolysaccharides with their accumulation and polymerization in the course of hypothyroidism, as well as accumulation of biogenic monoamines (noradrenaline and serotonin) in the endothelium of the precapillary arterioles and capillaries. The changes discovered may be taken as a basis for the explanation of some neurological and especially vascular manifestations on the part of the nervous system in patients with hypothyroidism.
ISSN:	0044-4588