Effect of hydrocortisone on the phospholipid composition and activity of various enzymes of phospholipid metabolism in the nuclear membranes of the rat liver

It was shown that hydrocortisone injections markedly increase the total content of liver nuclear membrane phospholipids, the greatest increase being observed in the phosphatidyl choline level. It was found also that nuclear membranes contain phospholipid metabolism enzymes. The hormone-induced incre...

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Bibliographic Details
Published in:	Biokhimiia (Moscow, Russia) Vol. 51; no. 10; p. 1630
Main Authors:	Gevorkian, E S, Tadevosian, Iu V, Iavroian, Zh V, Gevorkian, G A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-10-1986
Subjects:	Acetyl-CoA C-Acyltransferase - antagonists & inhibitors Animals Female Hydrocortisone - pharmacology Liver - drug effects Liver - enzymology Liver - metabolism Male Membrane Lipids - antagonists & inhibitors Nuclear Envelope - enzymology Nuclear Envelope - metabolism Phospholipases - antagonists & inhibitors Phospholipids - metabolism Rats
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Summary:	It was shown that hydrocortisone injections markedly increase the total content of liver nuclear membrane phospholipids, the greatest increase being observed in the phosphatidyl choline level. It was found also that nuclear membranes contain phospholipid metabolism enzymes. The hormone-induced increase in the phospholipid content is accompanied by a marked decrease of the activity of phospholipase A2 (5.3 times against control), phospholipase C (9.3 times) and acyl-CoA: lysophosphatidylcholine transferase (2.5 times). The results obtained are suggestive of appreciable metabolic changes in nuclear membrane phospholipids caused by hydrocortisone which, in turn, may be due to hormonal activation of the genome.
ISSN:	0320-9725