Synthesis of new (4-alkylamino-4'-fluoro)-diphenyl sulphones with potential biological activity

In the present work, we report the synthesis and characterization of five (4-alkylalmino-4'-fluoro)-diphenyl sulphones, four of which have not been described before. In a preliminary evaluation of their biological activity, these products showed no effect on several Gram-positive and Gram-negat...

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Bibliographic Details
Published in:	Anais da Academia Brasileira de Ciências Vol. 68; no. 2; p. 161
Main Authors:	de Sousa Júnior, P T, Miller, J, Giesbrecht, A M
Format:	Journal Article
Language:	English
Published:	Brazil 1996
Subjects:	Anti-Bacterial Agents Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Structure-Activity Relationship Sulfones - chemical synthesis Sulfones - pharmacology Yeasts - drug effects
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Summary:	In the present work, we report the synthesis and characterization of five (4-alkylalmino-4'-fluoro)-diphenyl sulphones, four of which have not been described before. In a preliminary evaluation of their biological activity, these products showed no effect on several Gram-positive and Gram-negative bacteria and yeasts.
ISSN:	0001-3765