Effect of substance P on dopamine-beta-hydroxylase and phenethanolamine-N-methyltransferase in the adrenal glands of rats

Resulting from literature data concerning interactions between catecholamines and Substance P (SP) the influence of SP on the activity of dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) was studied in rat adrenals. Intraperitoneal application of SP (500 micrograms/k...

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Bibliographic Details
Published in:	Pharmazie Vol. 37; no. 8; p. 591
Main Authors:	Piesche, L, Oehme, P, Hilse, H, Hecht, K
Format:	Journal Article
Language:	German
Published:	Germany 01-08-1982
Subjects:	Adrenal Glands - enzymology Animals Catecholamines - pharmacology Dopamine beta-Hydroxylase - metabolism Humans Male Phenylethanolamine N-Methyltransferase - metabolism Rats Rats, Inbred Strains Stress, Psychological - enzymology Substance P - pharmacology
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Summary:	Resulting from literature data concerning interactions between catecholamines and Substance P (SP) the influence of SP on the activity of dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) was studied in rat adrenals. Intraperitoneal application of SP (500 micrograms/kg) to male Wistar rats 15 minutes before decapitation induced a decrease of PNMT activity in the adrenals, while DBH activity remained unchanged. After incubation of adrenals with SP (10(-6) mol/l) a decrease of activity of both PNMT and DBH was observed. The experimental results are discussed in connection with a normalizing function of SP during stress induced disorders.
ISSN:	0031-7144