A method of calculatiing immunochemical cross-reactions between homologous proteins

The effects of amino acid substitutions within the antigenic sites, within the residues close to these sites and within other parts of the molecule on the cross-reaction with the antisera to homologous protein were considered. The method for calculus the values of cross-reactions, based on using pri...

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Bibliographic Details
Published in:	Molekuliarnaia biologiia Vol. 21; no. 1; p. 39
Main Authors:	Maksiutov, A Z, Eroshkin, A M, Kulichkov, V A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1987
Subjects:	Amino Acids Animals Cross Reactions Epitopes - analysis Immunochemistry Mathematics Myoglobin - immunology Protein Conformation Species Specificity Whales - immunology
Online Access:	Get more information
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Summary:	The effects of amino acid substitutions within the antigenic sites, within the residues close to these sites and within other parts of the molecule on the cross-reaction with the antisera to homologous protein were considered. The method for calculus the values of cross-reactions, based on using primary structures data, X-ray coordinate of one of the homologues and the locations of the antigenic sites is proposed. The values obtained by this method for the cross-reactions of ten myoglobins from various species with antisperm-whale myoglobin sera have a good correlation with the known experimental data. The possibility of using the method to make the location of protein antigenic sites more precise is discussed.
ISSN:	0026-8984