Reversal of withdrawal injuries of the heart and liver by adaptation to intermittent hypoxia when discontinuing ethanol in chronically alcoholized animals

Adaptation to intermittent hypoxia in the hypobaric altitude chamber showed a two-fold decrease in ethanol consumption in chronically alcoholized rats and attenuated or arrested the withdrawal syndrome. The impact of adaptation to the withdrawal syndrome was that it prevented the development of with...

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Bibliographic Details
Published in:	Kardiologiia Vol. 32; no. 11-12; p. 78
Main Authors:	Meerson, F Z, Krasikov, S I, Chavkin, I I, Bikbulatov, M S, Tverdokhlib, V P
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1992
Subjects:	Adaptation, Physiological Animals Ethanol - adverse effects Heart Diseases - physiopathology Hypoxia - chemically induced Hypoxia - physiopathology Liver Diseases, Alcoholic - physiopathology Male Rats Substance Withdrawal Syndrome
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Summary:	Adaptation to intermittent hypoxia in the hypobaric altitude chamber showed a two-fold decrease in ethanol consumption in chronically alcoholized rats and attenuated or arrested the withdrawal syndrome. The impact of adaptation to the withdrawal syndrome was that it prevented the development of withdrawal analgesia, higher alcohol consumption after its withdrawal, withdrawal hepatic activation of lipid oxidation products and blood release of the hepatic specific enzymes fructose monophosphataldolase and gamma-glutamyl transpeptidase. Concurrently, the adaptation prevented the withdrawal fall of the cardiac fibrillation threshold and marked disorders of ventricular contraction and relaxation. The paper discusses whether adaptation to intermittent hypoxia can be used in the management of the types of alcoholism in whose development the withdrawal plays the key role.
ISSN:	0022-9040