Heterogeneity of basal membranes in human tissues detected by monoclonal antibodies to laminin and entactin

Heterogeneity of basal membranes in human tissues detected by monoclonal antibodies to laminin and entactin

The distribution of basal membrane glycoproteins, laminin and entactin, was studied immunohistochemically by peroxidase-antiperoxidase technique in different adult human organs: kidneys, liver, heart, skin, spleen and ileum. Monoclonal antibody against entactin (ELM2) reacted with all basal membrane...

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Bibliographic Details
Published in:Biulleten' eksperimental'noi biologii i meditsiny Vol. 105; no. 5; p. 611
Main Authors: Peklo, M M, Liubimov, A V, Printseva, O Iu
Format: Journal Article
Language:Russian
Published: Russia (Federation) 01-05-1988
Subjects:
Antibodies, Monoclonal
Antibody Specificity
Basement Membrane - analysis
Glycoproteins - analysis
Humans
Ileum - analysis
Immunoenzyme Techniques
Kidney - analysis
Laminin - analysis
Liver - analysis
Male
Membrane Glycoproteins
Middle Aged
Myocardium - analysis
Skin - analysis
Spleen - analysis
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Summary:The distribution of basal membrane glycoproteins, laminin and entactin, was studied immunohistochemically by peroxidase-antiperoxidase technique in different adult human organs: kidneys, liver, heart, skin, spleen and ileum. Monoclonal antibody against entactin (ELM2) reacted with all basal membranes. Monoclonal antibody against laminin (LT3.1), however, did not react with basal membranes of arterial smooth muscle cells, or with endothelial basal membranes of renal and hepatic sinusoid endothelium. Thus, LT3.1 antibody has revealed basal membrane heterogeneity by laminin. The possible immunochemical heterogeneity of basal membranes by entactin is also discussed.
ISSN:0365-9615