Nonenzymatic deamidation as a factor in protein aging
Amidation of two protein fractions of brain, heart and liver of senite rats was found to decrease by 15--21% as compared with that of young animals. This decrease was shown to be due to unstable amide groups. Strong evidence is presented favouring the preposition that in proteins the unstable amide...
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| Published in: | Voprosy biokhimii mozga Vol. 13; p. 127 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | Russian |
| Published: |
Armenia (Republic)
1978
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| Abstract | Amidation of two protein fractions of brain, heart and liver of senite rats was found to decrease by 15--21% as compared with that of young animals. This decrease was shown to be due to unstable amide groups. Strong evidence is presented favouring the preposition that in proteins the unstable amide groups are those of asparagine and the stable ones those of glutamine. The possibility of the nonenzymatic deamidation of proteins was investigated. Deaminated proteins were found to be more easily attacked by proteinases which could be one of the possible ways of breakdown of aging proteins. |
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| AbstractList | Amidation of two protein fractions of brain, heart and liver of senite rats was found to decrease by 15--21% as compared with that of young animals. This decrease was shown to be due to unstable amide groups. Strong evidence is presented favouring the preposition that in proteins the unstable amide groups are those of asparagine and the stable ones those of glutamine. The possibility of the nonenzymatic deamidation of proteins was investigated. Deaminated proteins were found to be more easily attacked by proteinases which could be one of the possible ways of breakdown of aging proteins. |
| Author | Lukash, A I Mendzheritskiĭ, A M Sherstnev, K B Krichevskaia, A A Pushkina, N V |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/756639$$D View this record in MEDLINE/PubMed |
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| Snippet | Amidation of two protein fractions of brain, heart and liver of senite rats was found to decrease by 15--21% as compared with that of young animals. This... |
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| StartPage | 127 |
| SubjectTerms | Aging Amides - metabolism Animals Brain - metabolism Liver - metabolism Myocardium - metabolism Organ Specificity Proteins - metabolism Rats Time Factors |
| Title | Nonenzymatic deamidation as a factor in protein aging |
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