Nonenzymatic deamidation as a factor in protein aging

Amidation of two protein fractions of brain, heart and liver of senite rats was found to decrease by 15--21% as compared with that of young animals. This decrease was shown to be due to unstable amide groups. Strong evidence is presented favouring the preposition that in proteins the unstable amide...

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Bibliographic Details
Published in:	Voprosy biokhimii mozga Vol. 13; p. 127
Main Authors:	Krichevskaia, A A, Lukash, A I, Pushkina, N V, Sherstnev, K B, Mendzheritskiĭ, A M
Format:	Journal Article
Language:	Russian
Published:	Armenia (Republic) 1978
Subjects:	Aging Amides - metabolism Animals Brain - metabolism Liver - metabolism Myocardium - metabolism Organ Specificity Proteins - metabolism Rats Time Factors
Online Access:	Get more information
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Summary:	Amidation of two protein fractions of brain, heart and liver of senite rats was found to decrease by 15--21% as compared with that of young animals. This decrease was shown to be due to unstable amide groups. Strong evidence is presented favouring the preposition that in proteins the unstable amide groups are those of asparagine and the stable ones those of glutamine. The possibility of the nonenzymatic deamidation of proteins was investigated. Deaminated proteins were found to be more easily attacked by proteinases which could be one of the possible ways of breakdown of aging proteins.
ISSN:	0507-2972