Mechanism of the reaction of substrate phosphorylation in the tricarboxylic acid cycle

Mechanism of the reaction of substrate phosphorylation in the tricarboxylic acid cycle

The suggested sequence of the reactions differs from those presented in literature and includes the following compounds as intermediate ones: the complex of enzyme having 2ATP and two residues of phosphoric acid; the complex of enzyme having four residues of phosphoric acid; the complex of enzyme co...

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Bibliographic Details
Published in:Ukrainskij biohimičeskij žurnal Vol. 50; no. 1; p. 121
Main Authors: Matveeva, L N, Mikeladze, D G, Severin, S E
Format: Journal Article
Language:Russian
Published: Ukraine 01-01-1978
Subjects:
Adenosine Triphosphate - metabolism
Citric Acid Cycle
Coenzyme A - metabolism
Succinates - metabolism
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Summary:The suggested sequence of the reactions differs from those presented in literature and includes the following compounds as intermediate ones: the complex of enzyme having 2ATP and two residues of phosphoric acid; the complex of enzyme having four residues of phosphoric acid; the complex of enzyme containing two residues of phosphoric acid and two residues of succinic acid. Sequences of the reactions suggested in literature involve as intermediate compounds a phosphorylated derivative of the enzyme (E--P), phosphorylated derivative CoA linked with the enzyme (E.CoA--P), a high-ergic compound of the enzyme with CoA (E.CoA) and succinyl phosphate linked with the enzyme (E.succinyl--P).
ISSN:0201-8470