Inhibition of 3-H-noradrenalin uptake in synaptosomes by substance P

The uptake kinetics of DL-[3H]-norepinephrine into synaptosomes from rat brain hypothalamus can be described as a two stage process with uptake constants of Km = 0.9 micron and Km = 0.06 micron, respectively. Substance P exerts an inhibiting influence on both uptakes. The possible importance of this...

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Bibliographic Details
Published in:	Acta biologica et medica Germanica Vol. 36; no. 9; p. 1351
Main Authors:	Piesche, L, Hilse, H, Scheer, E, Bienert, M, Oehme, P
Format:	Journal Article
Language:	English
Published:	Germany 1977
Subjects:	Animals Male Norepinephrine - metabolism Rats Substance P - physiology Synaptic Transmission Synaptosomes - metabolism
Online Access:	Get more information
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Summary:	The uptake kinetics of DL-[3H]-norepinephrine into synaptosomes from rat brain hypothalamus can be described as a two stage process with uptake constants of Km = 0.9 micron and Km = 0.06 micron, respectively. Substance P exerts an inhibiting influence on both uptakes. The possible importance of this inhibition for the regulation of noradrenergic transmission is discussed.
ISSN:	0001-5318