7-Substituted theophyllines. Part I. Nicotinamide derivatives

Some nicotinamides derived from 7-substituted theophyllines were prepared and pharmacologically screened. They showed a very low coronarodilatory activity, a remarkable antispastic activity and a low toxicity.

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Bibliographic Details
Published in:	Il Farmaco; edizione scientifica Vol. 34; no. 4; p. 284
Main Authors:	Duranti, E, Bonifazi, P, Balsamini, C, Peruzzi, G, Lombardelli, G
Format:	Journal Article
Language:	English
Published:	Italy 01-04-1979
Subjects:	Acetylcholine - antagonists & inhibitors Aminophylline - pharmacology Animals Female Guinea Pigs Heart - drug effects Histamine Antagonists - pharmacology Ileum - drug effects Male Mice Niacinamide - analogs & derivatives Niacinamide - chemical synthesis Niacinamide - pharmacology Theophylline - analogs & derivatives Theophylline - chemical synthesis Theophylline - pharmacology
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Description
Summary:	Some nicotinamides derived from 7-substituted theophyllines were prepared and pharmacologically screened. They showed a very low coronarodilatory activity, a remarkable antispastic activity and a low toxicity.
ISSN:	0430-0920