Effect of diacarb and furosemide in combination with cytostatics on the mitotic activity of tumor and intestines of rats with sarcoma 45

• Published in: Farmakologiia i toksikologiia Vol. 40; no. 2; p. 215
• Main Authors: Aref'eva, A K, Pashinskiĭ, V G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-03-1977
• Subjects: Acetazolamide - administration & dosage; Acetazolamide - therapeutic use; Animals; Cyclophosphamide - administration & dosage; Cyclophosphamide - therapeutic use; Drug Therapy, Combination; Furosemide - administration & dosage; Furosemide - therapeutic use; Intestinal Mucosa - pathology; Mercaptopurine - administration & dosage; Mercaptopurine - therapeutic use; Mitosis; Rats; Sarcoma, Experimental - drug therapy; Sarcoma, Experimental - pathology
• ISSN: 0014-8318

A cytological analysis of proliferating neoplasic and intestinal epithelium tissues of rats under the effect of cyclophosphane, 6-mercaptopurine, furosemide, diacarbum and of their combination with course-wise introduction was effected. The treatment of rats with the combination of these agents is shown to have led to a stronger inhibition of the mitotic activity in sarcoma 45 and to deeper morphological changes therein, as compared with separate administration of the antiblastomatous drugs. The mitotic activity of the intestinal crypts epithelium inhibited by cytostatics was completely restored up to the control level when the latter were used in combination with diuretics.