Change in the activity of NAD- and NADP-specific malate dehyrdogenases in oxygen deficiency in different tissues

NAD-dependent malate dehydrogenase (1.1.1.37) activity was markedly decreased under hypoxia in rat brain and liver mitochondria and cytoplasm; most significant decrease was observed in brain cortex mitochondria. NADP-dependent malate dehydrogenase (1.1.1.40) activity was also reduced under these con...

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Bibliographic Details
Published in:	Voprosy meditsinskoi khimii Vol. 21; no. 1; p. 73
Main Authors:	Eshchenko, N D, Golubev, A G, Osadchaia, L M, Putilina, F E
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1975
Subjects:	Animals Brain - cytology Brain - metabolism Cell Fractionation Centrifugation Cytoplasm - enzymology Hypoxia - chemically induced Hypoxia - enzymology Liver - cytology Liver - metabolism Malate Dehydrogenase - metabolism Mitochondria - enzymology NADH, NADPH Oxidoreductases - metabolism Nitrites - administration & dosage Oxaloacetates - metabolism Rats Sodium Subcellular Fractions - enzymology Time Factors
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Summary:	NAD-dependent malate dehydrogenase (1.1.1.37) activity was markedly decreased under hypoxia in rat brain and liver mitochondria and cytoplasm; most significant decrease was observed in brain cortex mitochondria. NADP-dependent malate dehydrogenase (1.1.1.40) activity was also reduced under these conditions and the most considerable changes were found in liver mitochondria and cytoplasm. Distribution of activities of these enzymes between subcellular fractions of brain and liver did not change under hypoxia. The oxaloacetate level rised by 20% in brain and decreased by 20-25% in liver under hypoxia.
ISSN:	0042-8809