Ultrastructural characteristics of experimental tumors of the intestine

Tumors of the rat large intestine induced by subcutaneous injection of 1,2-dimethylhydrazine were studied by the method of electron microscopy. Adenocarcinomas retained histiotypical differentiation and at the same time consisted mostly of cells with a low rate of differentiation. Just on the contra...

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Bibliographic Details
Published in:	Voprosy onkologij Vol. 22; no. 1; p. 59
Main Authors:	Pozharisskiĭ, K M, Savost'ianov, G A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1976
Subjects:	Adenocarcinoma - pathology Adenocarcinoma, Mucinous - pathology Animals Cell Differentiation Intestinal Neoplasms - pathology Intestine, Large - ultrastructure Male Neoplasms, Experimental - pathology Rats
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Summary:	Tumors of the rat large intestine induced by subcutaneous injection of 1,2-dimethylhydrazine were studied by the method of electron microscopy. Adenocarcinomas retained histiotypical differentiation and at the same time consisted mostly of cells with a low rate of differentiation. Just on the contrary, in mucous and signet-ring cell carcinomas the picture of an advanced cell differentiation was observed in a complete loss of organogeny. The greatest malignancy of neoplasms (signet-ring carcinoma), which cells are characterized by a high degree of cytological differentiation, is a manifestation of independence of tumor progression signs.
ISSN:	0507-3758