Changes in pressor and depressor reactions following partial pancreatectomy

Experiments were conducted on 39 mongrel pubertal dogs. The course of pressor and depressor reactions under conditions of normal vital activity and after partial corporocaudal resection of the pancreas was studied. The principal indices characterizing the changes of pressor reaction to noradrenaline...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 87; no. 2; p. 103
Main Authors:	Rzaev, N M, Abaskulieva, L I, Khanumova, T A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-02-1979
Subjects:	Animals Arrhythmias, Cardiac - etiology Blood Pressure Bradykinin - pharmacology Cardiovascular Physiological Phenomena Dogs Heart Conduction System - physiology Heart Rate Islets of Langerhans - physiology Kallikreins - pharmacology Norepinephrine - pharmacology Pancreatectomy - adverse effects Venous Pressure
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Summary:	Experiments were conducted on 39 mongrel pubertal dogs. The course of pressor and depressor reactions under conditions of normal vital activity and after partial corporocaudal resection of the pancreas was studied. The principal indices characterizing the changes of pressor reaction to noradrenaline, and of the depressor one -- to bradykinin and kallikrein before and 10 to 12 days after the corporocaudal resection of the pancreas were determined. Resection of the corporo-caudal part of the pancreas intensified the pressor reactions to noradrenaline, and depressor ones to bradykinin and kallikrein; it increased the initial negative chronotropic effect of catecholamines on the heart, and also enhanced the positive chronotropic effect of noradrenaline, kallikrein and bradykinin on the heart.
ISSN:	0365-9615