Protein amidation in the aging organism

The role of protein amide groups was studied in the process of the organism ageing. It is shown that with ageing there occurs the asparagin deamidation in water-soluble and water-insolbule proteins of the rat brain, liver and heart. The glutamine content in the old rat tissues remains at the level d...

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Bibliographic Details
Published in:	Ukrainskij biohimičeskij žurnal Vol. 51; no. 6; p. 680
Main Author:	Pushkina, N V
Format:	Journal Article
Language:	Russian
Published:	Ukraine 01-11-1979
Subjects:	Aging Amides - metabolism Animals Asparagine - metabolism Brain - growth & development Brain - metabolism Glutamine - metabolism Heart - growth & development Liver - growth & development Liver - metabolism Myocardium - metabolism Organ Specificity Rats
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Summary:	The role of protein amide groups was studied in the process of the organism ageing. It is shown that with ageing there occurs the asparagin deamidation in water-soluble and water-insolbule proteins of the rat brain, liver and heart. The glutamine content in the old rat tissues remains at the level determined in the young animal tissues. Tissue proteins of old rats are better substrates for protein--a complex of proteinases of a wide specificity that those of young animals. An increased attack of the old animals proteins by nonspecific proteinases is due to a decrease in their amidation degree during ageing.
ISSN:	0201-8470